Clobex - Anti-infective

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Clobex® is an antibacterial agent with bactericidal activity against most Gram-positive organisms and it is indicated for the treatment of skin and soft tissue infections, respiratory tract infections etc.
•   Prevents pyelonephritis & other recurrent UTIs during pregnancy
•   Superior efficacy & safety in SSTIs during pregnancy
•   Offers better patients' compliance in gestational period
•   Highly effective in RTIs

Clobex®
Capsule/Syrup
Description
Clobex (Cloxacillin) is a b lactamase resistant antibacterial agent with
bactericidal activity against most Gram-positive organisms and Neisseria
spp. It is also effective against b lactamase producing Gram-negative
organisms when given with Ampicillin.
Indications
Clobex is indicated for the treatment of infections caused by Grampositive
organisms including infections caused by b lactamase producing
Staphylococci such as :
¨ Skin and soft tissue infections : Boils, Abscesses, Carbuncles,
Furunculosis, Cellulitis, Infected wounds, Infected burns, Otitis media
and externa, Protection of skin graft and Skin infections like ulcer,
eczema, acne, etc.
¨ Respiratory tract infections : Pneumonia, Lung abscess, Empyema,
Sinusitis, Pharyngitis and Tonsillitis.
¨ Other infections caused by sensitive organisms : Osteomyelitis,
Enteritis, Endocarditis, Urinary tract infection, Meningitis and
Septicaemia.
Dosage and Administration
Adult : Usual dose is 500 mg 6 hourly daily
Children (2-10 years) : 250 mg 6 hourly daily
Children (up to 2 years) : 125 mg (i.e. 1 measuring spoonful of
Clobex Syrup) 6 hourly daily
Dose may be doubled in severe infection and should be taken at least 30
minutes before food.
Contraindication
Clobex should not be given to patients known to be hypersensitive to
penicillin.
Precautions
Clobex should be given with caution to patients with known history of
allergy.
Side Effects
Common side effects are skin rash, transient diarrhoea, nausea,
heartburn, pruritus and disturbance of blood electrolyte. Rarely
anaphylactic shock.
Commercial Packs
Clobex® Capsule : Box containing 100 capsules in 10 x 10’s foil strips,
each capsule contains Cloxacillin Sodium BP equivalent to 500 mg
Cloxacillin.
Clobex® Syrup : Dry powder in glass bottle for reconstitution into 100 ml
syrup. After reconstitution each 5 ml contains Cloxacillin Sodium BP
equivalent to 125 mg Cloxacillin.

Source: Beximco Pharma