Cosmotrin® cream is a topical anti-acne preparation containing Tretinoin which stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones, papules and pustules. It is indicated for topical application in the treatment of acne vulgaris in which comedones, papules and pustules predominate.
• Treats acne effectively
• First line treatment of acne as it roots out the root cause of acne
• Satisfies patients' needs of treatment as well as beauty
• Convenient once daily application
Description Cosmotrin cream is a topical anti-acne preparation containing Tretinoin USP 0.025%. Topical Tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally Tretinoin stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones, papules and pustules.
Indications For topical application in the treatment of acne vulgaris in which comedones, papules and pustules predominate.
Dosage and Administration Cosmotrin cream should be applied sparingly to the whole affected area once or twice daily. The skin should be thoroughly cleaned and dried before application. Patient should be advised that 6 to 8 weeks of treatment may be required before a therapeutic effect is observed. Moisturisers and cosmetics may be used during treatment with Cosmotrin cream but should not be applied to the skin at the same time. Astringent toiletries should be avoided.
Contraindications Tretinoin is contraindicated to those who are highly sensitive to any of the ingredients. This cream should not be used in patients with a personal or family history of cutaneous epithelioma (skin cancer).
Precautions Avoid contact of Tretinoin with lips, mouth, eyes, eyelids, nostrils or other mucous membrane. If contact in these areas occur, careful washing with water is recommended. Apply the cream to sensitive areas of skin, such as the neck, with caution. Do not use it on broken, eczematous or sun burned skin.
Drug Interactions Other topical acne treatments should be used with caution during treatment with Tretinoin. Particular caution should be exercised when using preparation containing a peeling agent for example benzoyl peroxide. It is also possible to apply Tretinoin and benzoyl peroxide alternately. The suggested regimens are either Tretinoin in the morning and benzoyl peroxide in the evening or the preparations should be used on alternate days.
Side Effects Initial external application of Tretinoin generally may cause burning or slight irritation. Erythema and peeling at the site of application. If irritation becomes severe and persists, application should be discontinued and consultation with physician is required, if necessary.
Use in Special Population Pregnancy and lactation : There is an inadequate evidence of the safety of topically applied Tretinoin cream during pregnancy. Tretinoin has been associated with teratogenicity in human when administered systemically. So, the cream should not be used during pregnancy and lactation.
Source: Beximco Pharma
